{"id":11475,"date":"2025-09-03T18:38:37","date_gmt":"2025-09-03T22:38:37","guid":{"rendered":"https:\/\/parmaks.com\/Resources\/dr-dominic-dagostino-all-things-ketones-how-to-protect-the-brain-and-boost-cognition-sardine-fasting-diet-rules-revisiting-metformin-and-melatonin-and-more-825\/"},"modified":"2025-09-03T18:38:37","modified_gmt":"2025-09-03T22:38:37","slug":"dr-dominic-dagostino-all-things-ketones-how-to-protect-the-brain-and-boost-cognition-sardine-fasting-diet-rules-revisiting-metformin-and-melatonin-and-more-825","status":"publish","type":"post","link":"https:\/\/parmaks.com\/Resources\/dr-dominic-dagostino-all-things-ketones-how-to-protect-the-brain-and-boost-cognition-sardine-fasting-diet-rules-revisiting-metformin-and-melatonin-and-more-825\/","title":{"rendered":"Dr. Dominic D\u2019Agostino \u2014 All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More (#825)"},"content":{"rendered":"<p> <a href=\"https:\/\/hop.clickbank.net\/?affiliate=infohatch&amp;vendor=J1R2C\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-10614 aligncenter\" src=\"http:\/\/parmaks.com\/Resources\/wp-content\/uploads\/2025\/05\/profit-gen400px.png\" alt=\"Profit Gen\" width=\"400\" height=\"217\" srcset=\"https:\/\/parmaks.com\/Resources\/wp-content\/uploads\/2025\/05\/profit-gen400px.png 400w, https:\/\/parmaks.com\/Resources\/wp-content\/uploads\/2025\/05\/profit-gen400px-300x163.png 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><br \/>\n<\/p>\n<div>\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n<p>\n<iframe loading=\"lazy\" title=\"All Things Ketones, How to Boost Cognition, Sardine Fasting, Diet Rules, &amp; More \u2014 Dr. Dom D\u2019Agostino\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/NB02_mF8qTs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/p>\n<\/figure>\n<p><strong>Dr. Dominic D\u2019Agostino <\/strong>(<a target=\"_blank\" href=\"https:\/\/x.com\/DominicDAgosti2\">@DominicDAgosti2<\/a>) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.<\/p>\n<p>He teaches medical neuroscience, physiology, nutrition, and neuropharmacology, and his research focuses on the development and testing of nutritional strategies and metabolic-based therapies for neurological disorders, cancer, and human performance optimization. His work spans both basic science and human clinical trials.<\/p>\n<p>He has a strong personal interest in environmental medicine and enhancing the safety and resilience of military personnel and astronauts. In this capacity, he served as a research investigator and crew member on NASA\u2019s Extreme Environment Mission Operations. His research has been supported by the Office of Naval Research, the Department of Defense, the National Institutes of Health, private organizations, and nonprofit foundations.<\/p>\n<p>He earned his B.S. in Nutritional Science and Biological Sciences from Rutgers University in 1998, followed by a predoctoral fellowship in Neuroscience and Physiology at Rutgers and the University of Medicine and Dentistry of New Jersey. He then completed postdoctoral training in Neuroscience at Wright State University\u2019s Boonshoft School of Medicine in 2004 and at University of South Florida Morsani College of Medicine in 2006.<\/p>\n<p>Please enjoy!<\/p>\n<p><strong>Listen to the episode on\u00a0<a href=\"https:\/\/podcasts.apple.com\/us\/podcast\/825-dr-dominic-dagostino-all-things-ketones-how-to\/id863897795?i=1000724786708\" target=\"_blank\" rel=\"noreferrer noopener\">Apple Podcasts<\/a>,\u00a0<a href=\"https:\/\/open.spotify.com\/episode\/5fEmZB11g3MA1G9QtqiaRM\" target=\"_blank\" rel=\"noreferrer noopener\">Sp<\/a><a href=\"https:\/\/open.spotify.com\/episode\/7fdiy8pEI8mZhgLeQzfAPb?si=s3pikjXpSC-S2FU5HgHLSw\" target=\"_blank\" rel=\"noreferrer noopener\">otify<\/a>,\u00a0<a href=\"https:\/\/overcast.fm\/+AAKebsAzkFo\" target=\"_blank\" rel=\"noreferrer noopener\">Overcast<\/a>,\u00a0<a href=\"https:\/\/podcastaddict.com\/podcast\/2031148#\" target=\"_blank\" rel=\"noreferrer noopener\">Podcast Addict<\/a>,\u00a0<a href=\"https:\/\/pca.st\/timferriss\" target=\"_blank\" rel=\"noreferrer noopener\">Pocket Casts<\/a>,\u00a0<a href=\"https:\/\/castbox.fm\/channel\/id1059468?country=us\" target=\"_blank\" rel=\"noreferrer noopener\">Castbox<\/a>,\u00a0<a target=\"_blank\" href=\"https:\/\/music.youtube.com\/playlist?list=PLuu6fDad2eJyWPm9dQfuorm2uuYHBZDCB\">YouTube Music<\/a>,\u00a0<a href=\"https:\/\/music.amazon.com\/podcasts\/9814f3cc-1dc5-4003-b816-44a8eb6bf666\/the-tim-ferriss-show\" target=\"_blank\" rel=\"noreferrer noopener\">Amazon Music<\/a>,\u00a0<a href=\"https:\/\/www.audible.com\/podcast\/The-Tim-Ferriss-Show\/B08K58QX5W\" target=\"_blank\" rel=\"noreferrer noopener\">Audible<\/a>, or on your favorite podcast platform. <a href=\"https:\/\/youtu.be\/NB02_mF8qTs\" target=\"_blank\" rel=\"noreferrer noopener\">Watch the conversation on YouTube<\/a>. <\/strong><\/p>\n<p><strong>This episode is brought to you by:<\/strong><\/p>\n<div class=\"wp-block-tim-podcast-link-main podcast-block wp-embed-aspect-16-9 wp-has-aspect-ratio\"><a class=\"podcast-block__link\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/podcasts.apple.com\/us\/podcast\/825-dr-dominic-dagostino-all-things-ketones-how-to\/id863897795?i=1000724786708\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"podcast-block__link-icon\" src=\"https:\/\/i0.wp.com\/tim.blog\/wp-content\/themes\/timferriss\/inc\/blocks\/podcast-link\/images\/apple-podcast.png?ssl=1\"\/><noscript><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/tim.blog\/wp-content\/themes\/timferriss\/inc\/blocks\/podcast-link\/images\/apple-podcast.png?ssl=1\" class=\"podcast-block__link-icon\"\/><\/noscript><span class=\"podcast-block__link-text-top\">Listen on<\/span><span class=\"podcast-block__link-text\">Apple Podcasts<\/span><\/a><\/div>\n<div class=\"wp-block-tim-podcast-link-main podcast-block wp-embed-aspect-16-9 wp-has-aspect-ratio\"><a class=\"podcast-block__link\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/open.spotify.com\/episode\/7fdiy8pEI8mZhgLeQzfAPb?si=s3pikjXpSC-S2FU5HgHLSw\"><img loading=\"lazy\" width=\"35\" height=\"35\" decoding=\"async\" class=\"podcast-block__link-icon\" src=\"https:\/\/tim.blog\/wp-content\/themes\/timferriss\/inc\/blocks\/podcast-link\/images\/spotify.svg\"\/><noscript><img loading=\"lazy\" width=\"35\" height=\"35\" decoding=\"async\" src=\"https:\/\/tim.blog\/wp-content\/themes\/timferriss\/inc\/blocks\/podcast-link\/images\/spotify.svg\" class=\"podcast-block__link-icon\"\/><\/noscript><span class=\"podcast-block__link-text-top\">Listen on<\/span><span class=\"podcast-block__link-text\">Spotify<\/span><\/a><\/div>\n<div class=\"wp-block-tim-podcast-link-main podcast-block wp-embed-aspect-16-9 wp-has-aspect-ratio\"><a class=\"podcast-block__link\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/overcast.fm\/+AAKebsAzkFo\"><img loading=\"lazy\" width=\"1000\" height=\"1000\" decoding=\"async\" class=\"podcast-block__link-icon\" src=\"https:\/\/tim.blog\/wp-content\/themes\/timferriss\/inc\/blocks\/podcast-link\/images\/overcast.svg\"\/><noscript><img loading=\"lazy\" width=\"1000\" height=\"1000\" decoding=\"async\" src=\"https:\/\/tim.blog\/wp-content\/themes\/timferriss\/inc\/blocks\/podcast-link\/images\/overcast.svg\" class=\"podcast-block__link-icon\"\/><\/noscript><span class=\"podcast-block__link-text-top\">Listen on<\/span><span class=\"podcast-block__link-text\">Overcast<\/span><\/a><\/div>\n<div class=\"podcast-player\">\n<div class=\"podcast-player-inner-wrap\">\n<p>Dr. Dominic D\u2019Agostino \u2014 All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More<\/p>\n<p><noscript><iframe src=\"https:\/\/www.art19.com\/shows\/58dacbdc-646e-4585-9914-19c3de11d1ba\/episodes\/db7a9d0a-6fb3-48b9-863b-f8f8b8dda5bc\/embed?type=micro\" style=\"width: 100%; height: 30px; border: 0 none;\" scrolling=\"no\"><\/iframe><\/noscript><\/div>\n<\/div>\n<p><strong>This episode is brought to you by\u00a0<\/strong><a href=\"https:\/\/drinkag1.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>AG1<\/strong><\/a><strong>!<\/strong>\u00a0I get asked all the time, \u201cIf you could use only one supplement, what would it be?\u201d My answer is usually\u00a0<a href=\"https:\/\/drinkag1.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\">AG1<\/a>, my all-in-one nutritional insurance. I recommended it in\u00a0<em>The 4-Hour Body<\/em>\u00a0in 2010 and did not get paid to do so. <strong>Right now, you\u2019ll get a 1-year supply of Vitamin D free with your first subscription purchase<\/strong>\u2014a vital nutrient for a strong immune system and strong bones.\u00a0<strong>Visit\u00a0<\/strong><a href=\"https:\/\/drinkag1.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>DrinkAG1.com\/Tim<\/strong><\/a><strong>\u00a0to claim this special offer today and receive your 1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase!\u00a0<\/strong><\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n<p><strong>This episode is brought to you by\u00a0<\/strong><a href=\"http:\/\/livemomentous.com\/Tim\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Momentous<\/strong><\/a><strong>\u00a0high-quality creatine and more!\u00a0<\/strong>Momentous offers high-quality supplements and products across a broad spectrum of categories, and I\u2019ve been testing their products for months now. I\u2019ve been using their\u00a0<a href=\"https:\/\/www.livemomentous.com\/pages\/tim-ferriss#section-tims-favorite-products-for-sleep\" target=\"_blank\" rel=\"noreferrer noopener\">magnesium threonate<\/a>,\u00a0<a href=\"https:\/\/www.livemomentous.com\/pages\/tim-ferriss#section-tims-favorite-products-for-sleep\" target=\"_blank\" rel=\"noreferrer noopener\">apigenin<\/a>, and\u00a0<a href=\"https:\/\/www.livemomentous.com\/pages\/tim-ferriss#section-tims-favorite-products-for-sleep\" target=\"_blank\" rel=\"noreferrer noopener\">L-theanine<\/a>\u00a0daily, all of which have helped me improve the onset, quality, and duration of my sleep. I\u2019ve also been using\u00a0<a href=\"https:\/\/www.livemomentous.com\/pages\/tim-ferriss#section-tims-favorite-products\" target=\"_blank\" rel=\"noreferrer noopener\">Momentous creatine<\/a>, and while it certainly helps physical performance, including poundage or wattage in sports, I use it primarily for mental performance (short-term memory, etc.). <strong><a target=\"_blank\" href=\"https:\/\/www.livemomentous.com\/tim\">Use code TIM at checkout and enjoy 35% off your first subscription order or 14% off your first one-time purchase<\/a>!\u00a0<\/strong><\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n<p><strong>This episode is brought to you by\u00a0<a href=\"http:\/\/helixsleep.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Helix Sleep<\/strong><\/a>!\u00a0<\/strong>Helix was selected as the best overall mattress of 2024 by\u00a0<em>Forbes,<\/em> <em>Fortune<\/em>, and <em>Wired<\/em> magazines and many others. With\u00a0<a href=\"http:\/\/helixsleep.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\">Helix<\/a>, there\u2019s a specific mattress to meet each and every body\u2019s unique comfort needs. Just take their quiz\u2014<a href=\"http:\/\/helixsleep.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\">only two minutes to complete<\/a>\u2014that matches your body type and sleep preferences to the perfect mattress for you. They have a 10-year warranty, and you get to try it out for a hundred nights, risk-free. They\u2019ll even pick it up from you if you don\u2019t love it.\u00a0<strong>And now, Helix is offering 27% off all mattress orders at\u00a0<a href=\"http:\/\/helixsleep.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\">HelixSleep.com\/Tim<\/a>.<\/strong><\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n<h3 class=\"wp-block-heading\">SELECTED LINKS FROM THE EPISODE<\/h3>\n<ul class=\"wp-block-list\">\n<li>Connect with <strong>Dr. Dominic D\u2019Agostino<\/strong>:<\/li>\n<\/ul>\n<p class=\"has-text-align-center\"><a href=\"http:\/\/ketonutrition.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">KetoNutrition.org<\/a>\u00a0|\u00a0<a href=\"https:\/\/www.facebook.com\/dominic.dagostino.1\" target=\"_blank\" rel=\"noreferrer noopener\">Facebook<\/a>\u00a0|\u00a0<a href=\"https:\/\/twitter.com\/DominicDAgosti2\" target=\"_blank\" rel=\"noreferrer noopener\">Twitter<\/a>\u00a0|\u00a0<a href=\"https:\/\/usf.academia.edu\/DominicDAgostino\" target=\"_blank\" rel=\"noreferrer noopener\">University of South Florida<\/a><\/p>\n<h3 class=\"wp-block-heading\">Dr. Dominic D\u2019Agostino\u2019s Past Appearances<\/h3>\n<h3 class=\"wp-block-heading\">Concepts &amp; Ideas<\/h3>\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.alzdiscovery.org\/cognitive-vitality\/blog\/what-apoe-means-for-your-health\" target=\"_blank\" rel=\"noreferrer noopener\">APOE3\/4 Genotype<\/a>: A genetic variant where individuals carry one copy each of the APOE3 and APOE4 alleles, associated with moderately increased risk of Alzheimer\u2019s disease compared to APOE3\/3 but lower risk than APOE4\/4.<\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2769828\/\" target=\"_blank\" rel=\"noreferrer noopener\">Type 3 Diabetes<\/a>: A term used to describe Alzheimer\u2019s disease as a form of insulin resistance and insulin deficiency that occurs specifically in the brain, characterized by impaired neuronal glucose metabolism.<\/li>\n<li><a href=\"https:\/\/peterattiamd.com\/peter-on-the-four-horsemen-of-chronic-disease\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Four Horsemen of Chronic Disease<\/a>: The four pillars of chronic disease, according to Dr. Peter Attia.<\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9966425\/\" target=\"_blank\" rel=\"noreferrer noopener\">Glucose Hypometabolism<\/a>: A state where the brain\u2019s ability to use glucose for energy is impaired, often occurring more than 10 years before the onset of Alzheimer\u2019s disease symptoms and considered a key feature of neurodegeneration.<\/li>\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.13607\" target=\"_blank\" rel=\"noreferrer noopener\">Neuroinflammation<\/a>: Inflammation of nervous tissue involving activation of microglia and astrocytes, considered a major driver of neurodegenerative diseases including Alzheimer\u2019s, Parkinson\u2019s, and multiple sclerosis.<\/li>\n<li><a href=\"https:\/\/diet.mayoclinic.org\/us\/blog\/2022\/how-to-make-the-keto-diet-healthy\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ketogenic Diet<\/a>: A very low-carbohydrate (typically under 50g per day), high-fat diet originally developed at Mayo Clinic in the 1920s to treat epilepsy, which forces the body to produce ketones for fuel instead of using glucose.<\/li>\n<li><a href=\"https:\/\/www.eatingwell.com\/article\/7669444\/low-carb-mediterranean-diet-plan\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mediterranean-Style Low-Carb Diet<\/a>: A modified version of the traditional Mediterranean diet that reduces carbohydrate intake while emphasizing vegetables, fish, olive oil, nuts, and healthy fats to support weight loss and blood sugar control.<\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10103874\/\" target=\"_blank\" rel=\"noreferrer noopener\">Exogenous Ketones<\/a>: Ketone bodies (primarily beta-hydroxybutyrate) that are consumed through nutritional supplements in the form of ketone salts, esters, or precursor compounds, allowing for rapid elevation of blood ketones without dietary restriction.<\/li>\n<li><a href=\"https:\/\/ketone.com\/blogs\/library\/exogenous-ketones-ketone-supplement-fundamentals\" target=\"_blank\" rel=\"noreferrer noopener\">Ketone Monoester vs. Diester vs. Salts<\/a>: Different forms of exogenous ketone supplements where monoesters provide the most efficient ketone elevation, diesters are bonds between two ketone molecules, and salts combine ketones with minerals like sodium or potassium.<\/li>\n<li><a href=\"https:\/\/keto-mojo.com\/glucose-ketone-index-gki\/\" target=\"_blank\" rel=\"noreferrer noopener\">Glucose Ketone Index (GKI)<\/a>: A ratio calculated by dividing blood glucose levels by ketone levels, used as a biomarker for metabolic health and the depth of ketosis, with lower values indicating better metabolic flexibility.<\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Fasting\" target=\"_blank\" rel=\"noreferrer noopener\">Fasting<\/a> and <a href=\"https:\/\/www.youtube.com\/watch?v=bjHTAhBgwoI\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cSardine Fasting\u201d<\/a>: Abstaining from food for therapeutic benefits, with \u201csardine fasting\u201d referring to a modified fasting approach where only sardines are consumed, providing protein while maintaining some benefits of fasting.<\/li>\n<li><a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/24058-autophagy\" target=\"_blank\" rel=\"noreferrer noopener\">Autophagy<\/a>: The body\u2019s cellular recycling process of cleaning out damaged organelles and proteins to regenerate newer, healthier cellular components, enhanced during periods of fasting and ketosis.<\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7358070\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cancer Cachexia<\/a>: A complex metabolic syndrome characterized by severe loss of muscle mass and body weight, often accompanied by anemia, weakness, and loss of appetite in cancer patients.<\/li>\n<li><a href=\"https:\/\/longevity.stanford.edu\/lifestyle\/2024\/05\/30\/metabolic-psychiatry-bridging-brain-and-metabolic-health\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metabolic Psychiatry<\/a>: An emerging field that uses metabolic interventions, particularly ketogenic diets and exogenous ketones, to treat mental health conditions by addressing underlying metabolic dysfunction in the brain.<\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7049400\/\" target=\"_blank\" rel=\"noreferrer noopener\">NLRP3 Inflammasome<\/a>: A multiprotein complex in immune cells that acts as a cellular sensor and triggers inflammatory responses, playing a crucial role in innate immunity and implicated in various neurodegenerative diseases.<\/li>\n<li><a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/circresaha.116.303936?doi=10.1161\/CIRCRESAHA.116.303936\" target=\"_blank\" rel=\"noreferrer noopener\">Metabolic Control of Epigenetic Regulation<\/a>: The concept that metabolites like beta-hydroxybutyrate can directly influence gene expression by acting as signaling molecules and histone deacetylase inhibitors, affecting cellular function and health.<\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-025-02253-4\" target=\"_blank\" rel=\"noreferrer noopener\">Redox Stress<\/a>: An imbalance in the cellular ratio of NAD+ to NADH that can impair mitochondrial function and energy production, often associated with aging and metabolic dysfunction.<\/li>\n<li><a href=\"https:\/\/www.mayoclinic.org\/tests-procedures\/hyperbaric-oxygen-therapy\/about\/pac-20394380\" target=\"_blank\" rel=\"noreferrer noopener\">Hyperbaric Oxygen Therapy (HBOT)<\/a>: A medical treatment involving breathing pure oxygen in a pressurized chamber at 1.5 to 3 times normal atmospheric pressure, used to enhance healing and treat various conditions including wound healing and carbon monoxide poisoning.<\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9147253\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lipid Energy Model<\/a>: A metabolic model explaining how LDL cholesterol and ApoB particles can be elevated on low-carbohydrate diets as they function as transport vehicles for mobilized fatty acids used for energy production.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6326857\/\" target=\"_blank\" rel=\"noreferrer noopener\">SARM (Selective Androgen Receptor Modulator)<\/a>: A class of therapeutic compounds designed to selectively bind to androgen receptors in specific tissues, potentially offering the muscle-building benefits of anabolic steroids with reduced androgenic side effects.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">Substances &amp; Drugs<\/h3>\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9243231\/\" target=\"_blank\" rel=\"noreferrer noopener\">Beta-Hydroxybutyrate (BHB)<\/a>: The primary ketone body produced during fat metabolism and ketosis, used as an alternative energy source for the brain and body.<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37508009\/\" target=\"_blank\" rel=\"noreferrer noopener\">1,3-Butanediol<\/a>: A ketone precursor and alcohol compound that is metabolized into beta-hydroxybutyrate (BHB) in the liver.<\/li>\n<li><a href=\"https:\/\/www.healthline.com\/nutrition\/mct-oil-101\" target=\"_blank\" rel=\"noreferrer noopener\">MCT Oil (Medium-Chain Triglyceride)<\/a>: A type of saturated fat that is readily absorbed and converted into ketones, commonly used in ketogenic diets.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7910963\/\" target=\"_blank\" rel=\"noreferrer noopener\">Creatine Monohydrate<\/a>: A supplement that helps regenerate ATP in muscles, known for improving exercise performance, strength, and potentially cognitive function.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554414\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lipopolysaccharide (LPS)<\/a>: A component of gram-negative bacterial cell walls used in research to induce systemic inflammation and study immune responses.<\/li>\n<li><a href=\"https:\/\/www.drugs.com\/zetia.html\" target=\"_blank\" rel=\"noreferrer noopener\">Ezetimibe (Zetia)<\/a>: A prescription medication that lowers cholesterol by inhibiting its absorption in the small intestine.<\/li>\n<li><a href=\"https:\/\/www.verywellhealth.com\/rapamycin-longevity-drug-8747905\" target=\"_blank\" rel=\"noreferrer noopener\">Rapamycin<\/a>: An immunosuppressive drug originally used to prevent organ rejection that has gained attention for potential anti-aging and longevity effects.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK518983\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metformin<\/a>: A first-line medication for type 2 diabetes that lowers blood glucose levels and has potential benefits for longevity and metabolic health.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10376565\/\" target=\"_blank\" rel=\"noreferrer noopener\">Berberine\/Dihydroberberine<\/a>: Plant-derived alkaloid compounds with glucose-lowering effects similar to metformin, used for metabolic health support.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551568\/\" target=\"_blank\" rel=\"noreferrer noopener\">GLP-1 Agonists<\/a>: A class of diabetes medications that mimic incretin hormones to regulate blood sugar and promote weight loss, including drugs like semaglutide and tirzepatide.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8720766\/\" target=\"_blank\" rel=\"noreferrer noopener\">SGLT-2 Inhibitors<\/a>: A class of diabetes medications that lower blood sugar by preventing glucose reabsorption in the kidneys, causing excess glucose to be excreted in urine.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10692436\/\" target=\"_blank\" rel=\"noreferrer noopener\">NAD Supplements<\/a>: Supplements like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) designed to boost cellular NAD+ levels for potential anti-aging benefits.<\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7708875\/\" target=\"_blank\" rel=\"noreferrer noopener\">Idebenone<\/a> \/ <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements-coenzyme-q10\/art-20362602\" target=\"_blank\" rel=\"noreferrer noopener\">CoQ10<\/a> \/ <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ubiquinol\" target=\"_blank\" rel=\"noreferrer noopener\">Ubiquinol<\/a>: Antioxidant compounds that support mitochondrial energy production and cellular health, with CoQ10 being essential for ATP synthesis.<\/li>\n<li><a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/22857-gamma-aminobutyric-acid-gaba\" target=\"_blank\" rel=\"noreferrer noopener\">GABA<\/a> \/ <a href=\"https:\/\/medicine.umich.edu\/dept\/psychiatry\/news\/archive\/202010\/phenibut-russian-cosmonaut-drug-you-can-buy-online-reduce-anxiety\" target=\"_blank\" rel=\"noreferrer noopener\">Phenibut<\/a>: Gamma-aminobutyric acid and related compounds that have calming, inhibitory effects on the central nervous system.<\/li>\n<li><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a682539.html\" target=\"_blank\" rel=\"noreferrer noopener\">Diphenhydramine (Benadryl)<\/a>: An over-the-counter antihistamine commonly used for allergies that causes drowsiness and is sometimes used as a sleep aid.<\/li>\n<li><a href=\"https:\/\/www.nccih.nih.gov\/health\/melatonin-what-you-need-to-know\" target=\"_blank\" rel=\"noreferrer noopener\">Melatonin<\/a>: A hormone naturally produced by the pineal gland that regulates the sleep-wake cycle and is commonly used as a sleep supplement.<\/li>\n<li><a href=\"https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1564\/ostarine\" target=\"_blank\" rel=\"noreferrer noopener\">Ostarine<\/a>: A selective androgen receptor modulator (SARM) that selectively targets muscle and bone tissue, mentioned for veterinary use in research contexts.<\/li>\n<li><a href=\"https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1087\/alpha-gpc\" target=\"_blank\" rel=\"noreferrer noopener\">Alpha GPC<\/a> \/ <a href=\"https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1053\/theanine\" target=\"_blank\" rel=\"noreferrer noopener\">Theanine<\/a>: Nootropic compounds where Alpha-GPC supports acetylcholine production for cognitive function and L-theanine promotes relaxation without sedation.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">Products &amp; Brands<\/h3>\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/audaciousnutrition.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">KetoStart (Audacious Nutrition)<\/a>: A ketone electrolyte supplement company founded by Dr. Dominic D\u2019Agostino\u2019s wife, specializing in exogenous ketone products.<\/li>\n<li><a href=\"https:\/\/qitone.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Qitone<\/a>: A brand that produces ketone diester powder supplements for enhancing ketosis and metabolic performance.<\/li>\n<li><a href=\"https:\/\/keto-mojo.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Keto-Mojo<\/a>: A company that manufactures portable blood glucose and ketone testing devices popular among those following ketogenic diets.<\/li>\n<li><a href=\"https:\/\/www.amazon.com\/dp\/B00JIK6CIW\/?tag=offsitoftimfe-20\" target=\"_blank\" rel=\"noreferrer noopener\">Abbott Precision Xtra<\/a>: A dual-purpose blood glucose and ketone monitoring system manufactured by Abbott for diabetes management and ketosis tracking.<\/li>\n<li><a href=\"http:\/\/drinklmnt.com\/tim\" target=\"_blank\" rel=\"noreferrer noopener\">LMNT<\/a>: An electrolyte supplement brand that provides sugar-free, keto-friendly hydration products with optimal sodium, potassium, and magnesium ratios.<\/li>\n<li><a href=\"https:\/\/www.levels.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Levels<\/a>: A metabolic health company that provides continuous glucose monitors (CGMs) paired with an app to help users optimize their blood sugar responses.<\/li>\n<li><a href=\"https:\/\/www.dexcom.com\/stelo\" target=\"_blank\" rel=\"noreferrer noopener\">Stelo<\/a>: An over-the-counter continuous glucose monitor developed by Dexcom for people without diabetes to track their glucose patterns.<\/li>\n<li><a href=\"https:\/\/www.gbhealthwatch.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">GB HealthWatch<\/a>: A genetic testing company that provides personalized reports for dyslipidemia and cardiovascular risk assessment based on DNA analysis.<\/li>\n<li><a href=\"https:\/\/dryfarmwines.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dry Farm Wines<\/a>: A wine company specializing in natural, low-sugar, additive-free wines that are lab-tested for purity and lower alcohol content.<\/li>\n<li><a href=\"https:\/\/www.amazon.com\/dp\/0375710515\/?tag=jordanharbing-20\" target=\"_blank\" rel=\"noreferrer noopener\">French Women Don\u2019t Get Fat: The Secret of Eating for Pleasure<\/a> by Mireille Guiliano: A bestselling lifestyle guide that reveals the \u201cFrench paradox\u201d of how French women stay slim while enjoying bread, wine, and three-course meals through principles of balance, quality over quantity, and eating for pleasure rather than restriction.<\/li>\n<li><a href=\"https:\/\/ketobrainz.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Keto Brainz<\/a>: A supplement brand that produces MCT powder enhanced with nootropic compounds to support both ketosis and cognitive function.<\/li>\n<li><a href=\"https:\/\/www.nutricost.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Nutricost<\/a> \/ <a href=\"https:\/\/www.questnutrition.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Quest<\/a>: Popular supplement brands that offer MCT powder products among their extensive product lines.<\/li>\n<li><a href=\"https:\/\/www.nordicnaturals.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Nordic Naturals<\/a>: A premium omega-3 supplement brand known for high-quality fish oil products with third-party purity testing and sustainable sourcing.<\/li>\n<li><a href=\"https:\/\/www.omegaquant.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">OmegaQuant<\/a>: A testing company that measures omega-3 fatty acid levels in blood to help individuals optimize their omega-3 status and cardiovascular health.<\/li>\n<li><a href=\"https:\/\/www.metabolicmind.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metabolic Mind<\/a>: An educational platform from the Baszucki Group that focuses on metabolic approaches to mental health and psychiatric conditions.<\/li>\n<li><a href=\"https:\/\/metpsy.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">MetPsy<\/a>: An app currently in development designed to provide metabolic therapy coaching and support for mental health applications.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">Institutions<\/h3>\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nih.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\">NIH (National Institutes of Health)<\/a>: The primary agency of the United States government responsible for biomedical and public health research.<\/li>\n<li><a href=\"https:\/\/www.usf.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">USF (University of South Florida)<\/a>: Public research university in Tampa where Dr. D\u2019Agostino is a professor.<\/li>\n<li><a href=\"https:\/\/health.usf.edu\/medicine\/byrd\/\" target=\"_blank\" rel=\"noreferrer noopener\">Byrd Alzheimer\u2019s Center<\/a>: Research institute at USF Health dedicated to Alzheimer\u2019s disease prevention, treatment and cure where Dr. D\u2019Agostino\u2019s wife worked.<\/li>\n<li><a href=\"https:\/\/www.buckinstitute.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Buck Institute for Research on Aging<\/a>: Independent biomedical research institute in California focused on extending healthy years of life.<\/li>\n<li><a href=\"https:\/\/www.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Harvard University<\/a>: Private Ivy League research university in Cambridge, Massachusetts where Chris Palmer and Georgia Ede are affiliated.<\/li>\n<li><a href=\"https:\/\/www.moffitt.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moffitt Cancer Center<\/a>: National Cancer Institute-designated comprehensive cancer center in Tampa collaborating with Dr. D\u2019Agostino.<\/li>\n<li><a href=\"https:\/\/www.stanford.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Stanford University<\/a>: Private research university in California where Shebani Sethi is affiliated.<\/li>\n<li><a href=\"https:\/\/www.ox.ac.uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">Oxford University<\/a>: Prestigious collegiate research university in England where Dr. Ally Houston is affiliated.<\/li>\n<li><a href=\"https:\/\/www.northwestern.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Northwestern University<\/a>: Private research university in Illinois where Dr. Nav Chandel conducts research.<\/li>\n<li><a href=\"https:\/\/www.ed.ac.uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Edinburgh<\/a>: Public research university in Scotland where Dr. Iain Campbell conducts research.<\/li>\n<li><a href=\"https:\/\/www.yale.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yale University<\/a>: Private Ivy League research university in Connecticut where Dr. Deep Dixit is a researcher.<\/li>\n<li><a href=\"https:\/\/www.gene.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Genentech<\/a>: American biotechnology corporation and subsidiary of Roche, pioneering in recombinant DNA technology.<\/li>\n<li><a href=\"https:\/\/www.metrobiotech.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metro International Biotech<\/a>: Clinical-stage pharmaceutical company developing NAD+ precursors and therapeutics like MIB-626.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">Relevant Resources &amp; Research<\/h3>\n<h3 class=\"wp-block-heading\">People<\/h3>\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/coconutketones.com\/mary-newport-md-bio-books\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mary Newport<\/a>: Physician and author who pioneered the use of MCT oil for Alzheimer\u2019s disease, founding medical director of newborn intensive care units in Florida.<\/li>\n<li><a href=\"https:\/\/www.theatlantic.com\/health\/archive\/2012\/02\/my-husband-alzheimers-patient\/252595\/\" target=\"_blank\" rel=\"noreferrer noopener\">Steve Newport<\/a>: Husband of Dr. Mary Newport, subject of a case report on using a ketone monoester for Alzheimer\u2019s disease who experienced significant improvements.<\/li>\n<li><a href=\"https:\/\/tim.blog\/2023\/09\/20\/sam-corcos\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sam Corcos<\/a>: Co-founder and CEO of <a href=\"https:\/\/www.levels.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Levels<\/a>, a health technology startup that uses continuous glucose monitors to help people understand how food affects their metabolic health.<\/li>\n<li><a href=\"https:\/\/www.niaaa.nih.gov\/news-events\/research-update\/memoriam-dr-richard-veech\" target=\"_blank\" rel=\"noreferrer noopener\">Richard Veech<\/a>: NIH researcher who developed the beta-hydroxybutyrate monoester and studied ketones for cognitive decline and neurological disorders.<\/li>\n<li><a href=\"https:\/\/tim.blog\/2023\/03\/14\/peter-attia-outlive\/\" target=\"_blank\" rel=\"noreferrer noopener\">Peter Attia<\/a>: Physician and longevity expert, known for the \u201cFour Horsemen\u201d concept, host of <a href=\"https:\/\/peterattiamd.com\/podcast\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Drive podcast<\/a> and author of the #1 <em>New York Times<\/em> bestseller <a href=\"https:\/\/www.amazon.com\/dp\/0593236599\/?tag=offsitoftimfe-20\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Outlive<\/em><\/a>.<\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/George_F._Cahill_Jr.\" target=\"_blank\" rel=\"noreferrer noopener\">George F. Cahill Jr.<\/a>: Scientist known for his historic fasting studies and research on metabolic physiology at Harvard Medical School.<\/li>\n<li><a href=\"https:\/\/www.bc.edu\/bc-web\/schools\/mcas\/departments\/biology\/people\/faculty-directory\/thomas-seyfried.html\" target=\"_blank\" rel=\"noreferrer noopener\">Thomas Seyfried<\/a>: Professor and cancer researcher at Boston College, colleague of Dr. D\u2019Agostino who studies metabolic approaches to cancer treatment.<\/li>\n<li><a href=\"https:\/\/www.issaonline.com\/blog\/post\/celebrating-the-life-and-legacy-of-frederick-dr-squat-hatfield\" target=\"_blank\" rel=\"noreferrer noopener\">Fred Hatfield (\u201cDr. Squat\u201d)<\/a>: Powerlifter and mentor to Dr. D\u2019Agostino who used a ketogenic diet for metastatic prostate cancer treatment.<\/li>\n<li><a href=\"https:\/\/valterlongo.com\/biography\/\" target=\"_blank\" rel=\"noreferrer noopener\">Valter Longo<\/a>: Researcher known for the Fasting Mimicking Diet and director of the <a href=\"https:\/\/gero.usc.edu\/longevity-institute\/\" target=\"_blank\" rel=\"noreferrer noopener\">USC Longevity Institute<\/a> studying aging and disease prevention.<\/li>\n<li><a href=\"https:\/\/www.matthewsfriends.org\/about-us\/our-stories\/adult\/mike-dancer\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mike Dancer<\/a>: Man whose experience with epilepsy and the ketogenic diet influenced Dr. D\u2019Agostino\u2019s research direction.<\/li>\n<li><a href=\"https:\/\/www.linkedin.com\/in\/samuel-henderson-806b984a\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sam Henderson<\/a>: Researcher who published <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2731764\/\" target=\"_blank\" rel=\"noreferrer noopener\">early research on AC-1202 (MCT oil) for Alzheimer\u2019s disease treatment<\/a>.<\/li>\n<li><a href=\"https:\/\/www.researchgate.net\/profile\/Jong-Rho\/3\" target=\"_blank\" rel=\"noreferrer noopener\">Jong Rho<\/a>: Researcher who highlighted <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29325899\/\" target=\"_blank\" rel=\"noreferrer noopener\">the importance of acetoacetate and acetone in seizure control mechanisms<\/a>.<\/li>\n<li><a href=\"https:\/\/drspencer.com\/about\/\" target=\"_blank\" rel=\"noreferrer noopener\">Spencer Nadolsky<\/a>: Physician who suggested Dr. D\u2019Agostino might be a hyperabsorber of cholesterol based on his lipid profiles.<\/li>\n<li><a href=\"https:\/\/tim.blog\/2022\/07\/27\/matt-kaeberlein-life-extension\/\" target=\"_blank\" rel=\"noreferrer noopener\">Matt Kaeberlein<\/a>: Aging researcher and professor at the University of Washington studying longevity and healthspan extension.<\/li>\n<li><a href=\"https:\/\/www.audaciousnutrition.com\/pages\/about-the-founder\" target=\"_blank\" rel=\"noreferrer noopener\">Csilla Ari D\u2019Agostino<\/a>: Neuroscientist, Dom\u2019s wife, and founder of <a href=\"https:\/\/www.audaciousnutrition.com\/pages\/about-the-founder\" target=\"_blank\" rel=\"noreferrer noopener\">Audacious Nutrition<\/a>.<\/li>\n<li><a href=\"https:\/\/tim.blog\/2016\/11\/06\/charles-poliquin-mass-building-program\/\" target=\"_blank\" rel=\"noreferrer noopener\">Charles Poliquin<\/a>: Late strength coach known for his innovative training methods and work with elite athletes worldwide.<\/li>\n<li><a href=\"https:\/\/www.apollohealthco.com\/dr-bredesen\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dale Bredesen<\/a>: Physician and researcher focused on Alzheimer\u2019s disease treatment and prevention through the ReCODE protocol.<\/li>\n<li><a href=\"https:\/\/www.feinberg.northwestern.edu\/faculty-profiles\/az\/profile.html?xid=11123\" target=\"_blank\" rel=\"noreferrer noopener\">Navdeep Chandel<\/a>: Researcher at Northwestern University studying cellular metabolism and its role in health and disease.<\/li>\n<li><a href=\"https:\/\/tim.blog\/2023\/03\/08\/dr-andrew-huberman\/\" target=\"_blank\" rel=\"noreferrer noopener\">Andrew Huberman<\/a>: Neuroscientist and professor at Stanford University, host of the popular <a href=\"https:\/\/www.hubermanlab.com\/podcast\" target=\"_blank\" rel=\"noreferrer noopener\">Huberman Lab podcast<\/a> on health and performance.<\/li>\n<li><a href=\"https:\/\/tim.blog\/2025\/07\/24\/dr-rhonda-patrick\/\" target=\"_blank\" rel=\"noreferrer noopener\">Rhonda Patrick<\/a>: Scientist and host of <a href=\"https:\/\/www.foundmyfitness.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">FoundMyFitness<\/a>, specializing in nutrition, aging, and disease prevention through lifestyle interventions.<\/li>\n<li><a href=\"https:\/\/www.buckinstitute.org\/about-us\/leadership-team\/eric-verdin\/\" target=\"_blank\" rel=\"noreferrer noopener\">Eric Verdin<\/a>: President and CEO of the Buck Institute for Research on Aging, studying metabolism and aging processes.<\/li>\n<li><a href=\"https:\/\/medicine.yale.edu\/profile\/vishwa-dixit\/\" target=\"_blank\" rel=\"noreferrer noopener\">Vishwa Deep Dixit<\/a>: Researcher at Yale University who studied the NLRP3 inflammasome and its role in metabolic health.<\/li>\n<li><a href=\"https:\/\/tim.blog\/2022\/11\/10\/chris-palmer\/\" target=\"_blank\" rel=\"noreferrer noopener\">Chris Palmer<\/a>: Harvard psychiatrist and author of <em><a href=\"https:\/\/www.amazon.com\/dp\/1637741588\/?tag=offsitoftimfe-20\" target=\"_blank\" rel=\"noreferrer noopener\">Brain Energy<\/a><\/em>, advocate for metabolic psychiatry approaches to mental health treatment.<\/li>\n<li><a href=\"https:\/\/baszuckigroup.com\/our-work\/metabolic-mental-health\/\" target=\"_blank\" rel=\"noreferrer noopener\">Matt Baszucki<\/a>: Son of David Baszucki, whose experience with bipolar disorder was treated with a ketogenic diet approach.<\/li>\n<li><a href=\"https:\/\/baszuckigroup.com\/who-we-are\/\" target=\"_blank\" rel=\"noreferrer noopener\">Jan and David Baszucki<\/a>: Founders of <a href=\"https:\/\/www.roblox.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Roblox<\/a>, philanthropists funding metabolic psychiatry research through the <a href=\"https:\/\/baszuckigroup.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Baszucki Brain Research Fund<\/a>.<\/li>\n<li><a href=\"https:\/\/profiles.stanford.edu\/shebani-sethi\" target=\"_blank\" rel=\"noreferrer noopener\">Shebani Sethi<\/a>: Psychiatrist at Stanford University researching metabolic approaches to mental health treatment.<\/li>\n<li><a href=\"https:\/\/www.psych.ox.ac.uk\/team\/ally-houston\" target=\"_blank\" rel=\"noreferrer noopener\">Ally Houston<\/a>: Researcher at Oxford University studying metabolism and brain function.<\/li>\n<li><a href=\"https:\/\/www.diagnosisdiet.com\/about\" target=\"_blank\" rel=\"noreferrer noopener\">Georgia Ede<\/a>: Harvard-trained psychiatrist and author of <em><a href=\"https:\/\/www.amazon.com\/dp\/1538739070\/?tag=offsitoftimfe-20\" target=\"_blank\" rel=\"noreferrer noopener\">Change Your Diet, Change Your Mind<\/a><\/em>, specializing in nutritional psychiatry.<\/li>\n<li><a href=\"https:\/\/edwebprofiles.ed.ac.uk\/profile\/dr-iain-campbell\" target=\"_blank\" rel=\"noreferrer noopener\">Iain Campbell<\/a>: Researcher at the University of Edinburgh studying bipolar disorder and metabolic interventions.<\/li>\n<li><a href=\"https:\/\/winningthefight.org\/update-on-deannas-progress-2025\/\" target=\"_blank\" rel=\"noreferrer noopener\">Deanna Tedone<\/a>: Individual with ALS who stabilized her condition using the \u201cDeanna Protocol\u201d nutritional approach.<\/li>\n<li><a href=\"https:\/\/keto-mojo.com\/speakers\/angela-poff\/\" target=\"_blank\" rel=\"noreferrer noopener\">Angela Poff<\/a> and <a href=\"https:\/\/www.linkedin.com\/in\/victoria-adelus-field\/\" target=\"_blank\" rel=\"noreferrer noopener\">Victoria Field<\/a>: Colleagues of Dr. D\u2019Agostino who run the <a href=\"https:\/\/www.metabolicinitiative.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metabolic Health Initiative<\/a> at the University of South Florida.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">SHOW NOTES<\/h3>\n<ul class=\"wp-block-list\">\n<li>[00:00:00] Start.<\/li>\n<li>[00:14:43] Why I\u2019m interested in ketogenic strategies for neurodegenerative prevention.<\/li>\n<li>[00:16:18] Mary and Steve Newport\u2019s ketone-linked temporary cognitive improvements.<\/li>\n<li>[00:18:18] A mechanisms overview for Alzheimer\u2019s\/dementia.<\/li>\n<li>[00:21:25] The immune system as longevity\u2019s \u201cfifth horseman\u201d \u2014 and why metabolic control is key.<\/li>\n<li>[00:22:04] How to measure ketones and GKI.<\/li>\n<li>[00:23:00] Fasting vs. ketogenic diet.<\/li>\n<li>[00:24:18] There\u2019s nothing fishy about sardine fasting.<\/li>\n<li>[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.<\/li>\n<li>[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.<\/li>\n<li>[00:31:57] Glucose tolerance testing revelations and CGM importance.<\/li>\n<li>[00:31:57] Upgrading the metabolic machinery through keto without getting bored.<\/li>\n<li>[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.<\/li>\n<li>[00:43:42] Dom\u2019s day-to-day diet regimen.<\/li>\n<li>[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.<\/li>\n<li>[00:51:30] Supplementing for sleep disruption while fasting.<\/li>\n<li>[00:55:41] Why Dom doesn\u2019t have misgivings about melatonin.<\/li>\n<li>[00:59:15] Shingles prevention through fasting protocols.<\/li>\n<li>[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.<\/li>\n<li>[01:03:54] Dom at 50-something: Current meal timing and composition.<\/li>\n<li>[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.<\/li>\n<li>[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.<\/li>\n<li>[01:15:18] Ketone metabolic therapy for cancer.<\/li>\n<li>[01:18:15] The metabolic psychiatry revolution.<\/li>\n<li>[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.<\/li>\n<li>[01:28:27] Metformin vs. berberine.<\/li>\n<li>[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.<\/li>\n<li>[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.<\/li>\n<li>[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.<\/li>\n<li>[01:42:05] Dom\u2019s supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.<\/li>\n<li>[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">DR. DOMINIC D\u2019AGOSTINO QUOTES FROM THE INTERVIEW<\/h3>\n<p><strong>\u201cI think the beauty of ketogenic [therapy] is that it\u2019s pleiotropic, right? Which means it\u2019s many mechanisms working in synergy.\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong>\u201cI think the best way to measure to suggest you\u2019re in autophagy is a glucose ketone index after a period of fasting.\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong>\u201cAbout 30 percent of the population hyperabsorbs cholesterol.\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong>\u201cHSCRP is a better indicator of cardiovascular disease than LDL cholesterol. We know that now. [No one would believe it] If someone said that 10 years ago.\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong>\u201cI wouldn\u2019t go above three, probably 1.5 to 2 millimolar range. That seems to be a level of ketones that safely does not produce a metabolic acidosis.\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong>\u201cWhen we published the NLRP3, I got requests from Genentech and various pharmaceutical companies to go there and give a talk on the mechanism so they could drugify. And I would throw up a big flow chart of all these mechanisms, and I think they would get frustrated. And it was like, \u2018Well, tell us the mechanism so we can make a drug out of this.\u2019\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong>\u201cI went on a vacation where I forgot melatonin and I slept like a baby probably because I was up every morning. The sun is the ultimate circadian synchronizer. I got off of melatonin to check my endogenous melatonin, and there was no suppression.\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong>\u201cSo we went to these blue zones and they just, at night after their dinner, the males will do a shot of alcohol, usually wine, but sometimes ouzo and they\u2019re all in their nineties and hundreds, they\u2019re in the blue zone. So it\u2019s a universal characteristic.\u201d<\/strong><\/p>\n<p>\u2014\u00a0Dr. Dominic D\u2019Agostino<\/p>\n<p><strong><a href=\"https:\/\/tim.blog\/2016\/09\/25\/dom-dagostino-on-disease-prevention-cancer-and-living-longer\/\" target=\"_blank\" rel=\"noreferrer noopener\">Want to hear<\/a> the last time Dom was on the show?<\/strong> Listen to <a href=\"https:\/\/tim.blog\/2016\/09\/25\/dom-dagostino-on-disease-prevention-cancer-and-living-longer\/\" target=\"_blank\" rel=\"noreferrer noopener\">our previous conversation<\/a> in which we discussed disease prevention, longevity, cancer, ketogenic diet mastery, the detoxifying effects of ketosis on pre-cancerous cells, how to jumpstart daily ketogenic cycles, \u201ccheat\u201d meals, <a href=\"https:\/\/tim.blog\/2016\/09\/25\/dom-dagostino-on-disease-prevention-cancer-and-living-longer\/\" target=\"_blank\" rel=\"noreferrer noopener\">and much more<\/a>.<\/p>\n<\/div>\n<p><script async src=\"\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><br \/>\n<br \/><a href=\"https:\/\/hop.clickbank.net\/?affiliate=infohatch&amp;vendor=J1R2C\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-10614 aligncenter\" src=\"http:\/\/parmaks.com\/Resources\/wp-content\/uploads\/2025\/05\/profit-gen400px.png\" alt=\"Profit Gen\" width=\"400\" height=\"217\" srcset=\"https:\/\/parmaks.com\/Resources\/wp-content\/uploads\/2025\/05\/profit-gen400px.png 400w, https:\/\/parmaks.com\/Resources\/wp-content\/uploads\/2025\/05\/profit-gen400px-300x163.png 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><br \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Dominic D\u2019Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11476,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-11475","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-growth"],"_links":{"self":[{"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/posts\/11475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/comments?post=11475"}],"version-history":[{"count":0,"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/posts\/11475\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/media\/11476"}],"wp:attachment":[{"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/media?parent=11475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/categories?post=11475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/parmaks.com\/Resources\/wp-json\/wp\/v2\/tags?post=11475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}